Contents: Statement of the statistical problem S atistical assumptions The experimenter's goal, specification, and requirement Procedure D and the new computing formulae Description of Procedure D Definition of symbols The sampling, stopping, and terminal de cision rules Computation of the stopping statistic Use of Procedure D (method B) with various experimental designs Simplified computing formulae Numerical example Monte Carlo sampling results with Procedure D Description of the sampling procedure Sampling results Discussion of sampling results.

The sequential probability ratin test; Sequential tests between three hypotheses; Extensions to the SPRT; Some applications of Cox's theorem; Some methods leading to closed boundaries; Decision theory; Sequential estimation; Sequential estimation of points on regression functions; Sequential estimation of points on quantal response curves; Double sampling; Selection procedures.

Work on sequential methods has recently developed considerably. This introductory text has been revised to include later developments and seeks to equip scientists with the knowledge and understanding of statistical methods used in the interpretation of quantitative data. As with the previous editions particular emphasis has been placed on methods which are of importance in practical applications.