How did the turtle get its shell? Why do roosters crow at the sun? Where do Backwoods people come from? A Mixed medicine bag contains 15 original tales by Mashpee Wampanoag storyteller, Mwalim *7).

Born of encounters between Indigenous women and Euro-American men in the first decades of the nineteenth century, the Plains Metis people occupied contentious geographic and cultural spaces. Living in a disputed area of the northern Plains inhabited by various Indigenous nations and claimed by both the United States and Great Britain, the Metis emerged as a people with distinctive styles of speech, dress, and religious practice, and occupational identities forged in the intense rivalries of the fur and provisions trade. Michel Hogue explores how, as fur trade societies waned and as state officials looked to establish clear lines separating the United States from Canada and Indians from non-Indians, these communities of mixed Indigenous and European ancestry were profoundly affected by the efforts of nation-states to divide and absorb the North American West. Grounded in extensive research in U.S. and Canadian archives, Hogue's account recenters historical discussions that have typically been confined within national boundaries and illuminates how Plains Indigenous peoples like the Metis were at the center of both the unexpected accommodations and the hidden history of violence that made the "world's longest undefended border."

Thanks to remarkable advances in modern health care attributable to science, engineering, and medicine, it is now possible to cure or manage illnesses that were long deemed untreatable. At the same time, however, the United States is facing the vexing challenge of a seemingly uncontrolled rise in the cost of health care. Total medical expenditures are rapidly approaching 20 percent of the gross domestic product and are crowding out other priorities of national importance. The use of increasingly expensive prescription drugs is a significant part of this problem, making the cost of biopharmaceuticals a serious national concern with broad political implications. Especially with the highly visible and very large price increases for prescription drugs that have occurred in recent years, finding a way to make prescription medicinesâ€"and health care at largeâ€"more affordable for everyone has become a socioeconomic imperative. Affordability is a complex function of factors, including not just the prices of the drugs themselves, but also the details of an individual's insurance coverage and the number of medical conditions that an individual or family confronts. Therefore, any solution to the affordability issue will require considering all of these factors together. The current high and increasing costs of prescription drugsâ€"coupled with the broader trends in overall health care costsâ€"is unsustainable to society as a whole. Making Medicines Affordable examines patient access to affordable and effective therapies, with emphasis on drug pricing, inflation in the cost of drugs, and insurance design. This report explores structural and policy factors influencing drug pricing, drug access programs, the emerging role of comparative effectiveness assessments in payment policies, changing finances of medical practice with regard to drug costs and reimbursement, and measures to prevent drug shortages and foster continued innovation in drug development. It makes recommendations for policy actions that could address drug price trends, improve patient access to affordable and effective treatments, and encourage innovations that address significant needs in health care.