Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.

A dramatic story of WWII espionage, betrayal, and loyalty, by the #1 bestselling author of Life After Life In 1940, eighteen-year old Juliet Armstrong is reluctantly recruited into the world of espionage. Sent to an obscure department of MI5 tasked with monitoring the comings and goings of British Fascist sympathizers, she discovers the work to be by turns both tedious and terrifying. But after the war has ended, she presumes the events of those years have been relegated to the past forever. Ten years later, now a radio producer at the BBC, Juliet is unexpectedly confronted by figures from her past. A different war is being fought now, on a different battleground, but Juliet finds herself once more under threat. A bill of reckoning is due, and she finally begins to realize that there is no action without consequence. Transcription is a work of rare depth and texture, a bravura modern novel of extraordinary power, wit and empathy. It is a triumphant work of fiction from one of the best writers of our time.

This two-volume book gives a broad coverage of various aspects of plant molecular biology relevant to the improvement of woody plants. The authors provide background information on genetic engineering and molecular marker techniques, and specific examples of species in which sufficient progress has been made.

Companion website, featuring additional resources such as sound files, can be found here: http://www.blackwellpublishing.com/phonetics/ Providing a comprehensive overview of the four primary areas of phonetics, Phonetics: Transcription, Production, Acoustics, and Perception is an ideal guide to the complete study of speech and sound. An accessible but in-depth introductory textbook on the basic concepts of phonetics Covers all four areas of phonetics: transcription, production, acoustics, and perception Offers uniquely thorough coverage of related relevant areas, including vocal fold vibration and the working of the ear, creating an engagingly flexible work for instructors Includes chapter-by-chapter exercises, enabling students to put their knowledge into practice Written in a clear and concise style by two of the field’s leading scholars

Substantial progress has been made in seed science during the past few years, emphasizing the important role seed biology plays in advancing plant biotechnology, agriculture and plant resource management and conservation. This book describes the status of seed research and technology.

An invaluable resource for computational biologists and researchers from other fields seeking an introduction to the topic, Chromatin: Structure, Dynamics, Regulation offers comprehensive coverage of this dynamic interdisciplinary field, from the basics to the latest research. Computational methods from statistical physics and bioinformatics are detailed whenever possible without lengthy recourse to specialized techniques.