This guide is designed to help teachers develop and implement HIV/AIDS education programs for students with special education needs. It presents specific suggestions for adapting curricula and teaching styles to meet the needs of individual students. The introduction discusses why students with special needs should receive HIV/AIDS education and what barriers to that education exist. It notes the elements necessary for quality HIV/AIDS education for students with special needs. The second component provides ideas for adapting instructions for students with special needs (e.g., determining the appropriate program, using a multisensory approach, and using task analysis). It includes adaptation strategies, a quick reference, and an HIV/AIDS checklist. The third component offers teaching activities with suggestions for adaptations to accommodate students with specific disabilities (e.g., learning disabilities, mental retardation, emotional disturbance, and visual impairment). The fourth component offers a list of references and resources on HIV/AIDS education for students with special needs. (SM).