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In his book about the discovery of the structure of DNA, James Watson wrote, “So we had lunch, telling ourselves that a structure this beautiful just had to exist.” Indeed, the quest most often asked by scientists about a scientific theory is “Is it beautiful?” Yes, beauty equals truth. Scientists know, mathematicians know. But the beauties, the truths of mathematics and science were not the truths that inspired the author as a child, and he intuitively knew that the truths he needed come from a different way of knowing, a way of knowing not of the world of logic and reason and explanation (though they have a value), but rather a way of knowing that is of the world expression, a world that enters the truths beyond the grasp of logic. That is what this book is all about. It is an exploration of the greatest minds of human existence struggling to understand the deepest truths of the human condition. This second edition updates the previous one, incorporating new publications on Van Gogh, recent discoveries in neurology, psychology, and the rapid developments in understanding DNA and biotechnology. We’ve come a long way already from that original discovery by Watson and his coauthor Francis Crick.