Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy
Title | Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy PDF eBook |
Author | Pawel Kalinski |
Publisher | Springer |
Pages | 271 |
Release | 2017-12-22 |
Genre | Medical |
ISBN | 331967577X |
The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
Tumor Microenvironment (TME) and Tumor Immune Microenvironment (TIME): New Perspectives for Prognosis and Therapy
Title | Tumor Microenvironment (TME) and Tumor Immune Microenvironment (TIME): New Perspectives for Prognosis and Therapy PDF eBook |
Author | Ana Karina de Oliveira |
Publisher | Frontiers Media SA |
Pages | 309 |
Release | 2022-09-30 |
Genre | Science |
ISBN | 283250132X |
The Heterogeneity of Cancer Metabolism
Title | The Heterogeneity of Cancer Metabolism PDF eBook |
Author | Anne Le |
Publisher | Springer |
Pages | 186 |
Release | 2018-06-26 |
Genre | Medical |
ISBN | 331977736X |
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Inflammatory Tumor Immune Microenvironment: Molecular Mechanisms and Signaling Pathways in Cancer Progression and Metastasis
Title | Inflammatory Tumor Immune Microenvironment: Molecular Mechanisms and Signaling Pathways in Cancer Progression and Metastasis PDF eBook |
Author | Xu Wang |
Publisher | Frontiers Media SA |
Pages | 448 |
Release | 2022-03-25 |
Genre | Medical |
ISBN | 2889747549 |
Tumor Microenvironment and Cancer Therapy
Title | Tumor Microenvironment and Cancer Therapy PDF eBook |
Author | Shoaquan Zheng |
Publisher | Frontiers Media SA |
Pages | 537 |
Release | 2023-10-17 |
Genre | Science |
ISBN | 2832536557 |
It is well established that the tumor microenvironment(TME) plays a pivotal role in tumor initiation, progression and therapeutic resistance by creating a dynamic interaction with cancer cells. TME is comprised of extracellular matrix (ECM), growth factors, nutrients, blood and lymphatic vessels, and non-cancer stromal cells, which serve as a sustained niche for cancer cells to proliferate and metastasize. Notably, various cellular components in TME, including endothelial cells, fibroblasts, pericytes, adipocytes, immune cells, cancer stem cells, and vasculature, could promote tumor’s immune evasion and growth.
Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy
Title | Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy PDF eBook |
Author | Salem Chouaib |
Publisher | Frontiers Media SA |
Pages | 196 |
Release | 2020-07-02 |
Genre | |
ISBN | 2889638170 |
The Tumor Immunoenvironment
Title | The Tumor Immunoenvironment PDF eBook |
Author | Michael R Shurin |
Publisher | Springer Science & Business Media |
Pages | 745 |
Release | 2013-03-19 |
Genre | Medical |
ISBN | 9400762178 |
Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.