The Louisiana 12th Infantry Regiment completed its organization at Camp Moore, Louisiana, in August, 1861. Its companies were from the parishes of Caldwell, Claiborne, Vermilion, Cameron, Calcasieu, Jackson, Ouachita, Bossier, and Iberia. Sent to Missouri, the unit was captured at Island No. 10 in April, 1862. After being exchanged, it was assigned to Rust's, Buford's, T.M. Scott's, and Lowry's Brigade. It fought at Champion's Hill and Jackson before participating in the campaigns of the Army of Tennessee from Resaca to Bentonville. In July, 1862, the unit contained 41 officers and 546 men, reported 11 killed, 57 wounded, and 5 missing out of the 318 engaged at Peach Tree Creek, lost many during Hood's Tennessee Campaign, and surrendered with only a remnant on April 26, 1865. Its commanders were Colonel Thomas M. Scott; Lieutenant Colonels James A. Boyd, Wade H. Hough, Noel L. Nelson, and Thomas C. Standifer; and Majors John C. Knott and Henry V. McCain.